abstract：:The treatment options for patients with recurrent head and neck malignancies arising in a previously irradiated field are limited. Surgical salvage is feasible in a minority of patients. The majority are referred for palliative chemotherapy with no realistic chance for cure. Data are accumulating to support reirradiat...

journal_title：Current opinion in oncology

authors： Garofalo MC,Haraf DJ

更新日期：2002-05-01 00:00:00

abstract：:Platinum-based combination and single-agent chemotherapy have become accepted as treatments for locally advanced and metastatic nonsmall cell lung cancer as a consequence of improved survival, quality of life, and symptom control compared with best supportive care. However, it is clear that a therapeutic plateau has b...

journal_title：Current opinion in oncology

authors： Booton R,Thatcher N

更新日期：2002-03-01 00:00:00

abstract：:Less than 1% of all cancers are present in the thyroid, yet thyroid nodules are found in 4 to 10% of the adult population. Because thyroid nodules are relatively common, the diagnostic dilemma is to distinguish between a more common benign nodule, which usually does not require specific treatment, and a malignant nodu...

journal_title：Current opinion in oncology

authors： Weiss RE,Lado-Abeal J

更新日期：2002-01-01 00:00:00

abstract：:Breast cancer remains a worldwide public health concern despite the fact that mortality rates have been declining in some countries as a result of improvements in adjuvant therapy and screening for breast cancer. In the prevention arena, advances in our understanding of the effects of tamoxifen have led to the investi...

journal_title：Current opinion in oncology

authors： Brewster A,Helzlsouer K

更新日期：2001-11-01 00:00:00

abstract：:Several epithelial tumors display epidermal growth factor receptor (EGFR) overexpression (with or without EGFR gene amplification) that is often associated with increased production of EGFR ligands. This permits the activation of endogenous tumor EGFR via autocrine mechanisms, resulting in cellular proliferation and t...

journal_title：Current opinion in oncology

authors： Arteaga CL,Johnson DH

更新日期：2001-11-01 00:00:00

abstract：:Mantle cell lymphoma is a distinct subtype and accounts for approximately 5 to 10% of non-Hodgkin lymphomas. The malignant cells express pan B-cell markers, including CD19, CD20 and CD22, and the T-cell marker CD5, whereas CD10 and CD23 expression are usually absent. By cytogenetic analysis, the t(11;14)(q13;q32) tran...

journal_title：Current opinion in oncology

authors： Leonard JP,Schattner EJ,Coleman M

更新日期：2001-09-01 00:00:00

abstract：:Given the burden of suffering associated with the development of ovarian cancer and the clear survival gradient related to the stage of disease at diagnosis, there is much enthusiasm for the development of effective screening strategies aimed at early detection. To date, no evidence exists to justify mass population s...

journal_title：Current opinion in oncology

authors： Paley PJ

更新日期：2001-09-01 00:00:00

abstract：:The cancer patient often presents with fever and pulmonary infiltrates, in particular during the course of chemotherapy or after bone marrow transplantation. In these conditions, specific diagnoses are mainly related to an infective cause, but noninfectious processes, malignant or not, are also found alone or in combi...

journal_title：Current opinion in oncology

authors： Ninane V

更新日期：2001-07-01 00:00:00

abstract：:Chemopreventive strategies hold substantial promise for reducing the incidence of colorectal cancer, the second leading cause of cancer-related mortality in the United States. This review focuses on recent advances in the identification of molecular targets and novel strategies for chemopreventive intervention. Many c...

journal_title：Current opinion in oncology

authors： Clapper ML,Chang WC,Meropol NJ

更新日期：2001-07-01 00:00:00

abstract：:Tyrosine kinase (type 1) growth factor receptors include the erbB family. These cell surface receptors were discovered in the context of cellular transformation and have subsequently been found to be overexpressed in many types of human cancer. Cumulative evidence suggests that upregulation of the most well-characteri...

journal_title：Current opinion in oncology

authors： Lango MN,Shin DM,Grandis JR

更新日期：2001-05-01 00:00:00

abstract：:In the past decade, the discovery of tumor antigens recognized by T cells has revolutionized the tumor vaccine field. The appreciation that peptides are bound to and restricted by major histocompatibility class I and II molecules for immune recognition has encouraged a number of early-phase clinical trials of peptide ...

journal_title：Current opinion in oncology

authors： Weber JS,Aparicio A

更新日期：2001-03-01 00:00:00

abstract：:The vast majority of adults with acute lymphoblastic leukemia (ALL) now achieve remission with current intensive chemotherapy regimens. Nevertheless, most adults with ALL will eventually relapse and die of their disease. Specific clinical and molecular-cytogenetic prognostic factors have been identified that are begin...

journal_title：Current opinion in oncology

authors： Verma A,Stock W

更新日期：2001-01-01 00:00:00

abstract：:Transforming growth factor-beta is believed to play a dual role in carcinogenesis. Through its ability to inhibit cellular proliferation it suppresses tumor development in its early stages, but in the course of tumor progression malignant cells often acquire resistance to growth inhibition by transforming growth facto...

journal_title：Current opinion in oncology

authors： Wieser R

更新日期：2001-01-01 00:00:00

abstract：:Approximately 1 in 10 US women will be diagnosed with breast cancer in her lifetime. With such a high incidence, breast cancer is a serious health concern for all American women. Within the past year, clues about the function of genes associated with breast cancer have been garnered, and novel genes that may contribut...

journal_title：Current opinion in oncology

authors： Unger MA,Weber BL

更新日期：2000-11-01 00:00:00

abstract：:The bcr-abl fusion protein is present in the vast majority of cases of chronic myelogenous leukemia, and the deregulated tyrosine kinase activity of this protein is essential for leukemic transformation. Thus, bcr-abl is an ideal target for pharmacologic inhibition. In preclinical studies, ST1571 (formerly CGP57148B),...

journal_title：Current opinion in oncology

authors： O'Dwyer ME,Druker BJ

更新日期：2000-11-01 00:00:00

abstract：:Family history plays an important role in breast, ovarian, and colorectal cancers. The increasing availability of genetic testing has forced women with these malignancies and their physicians to confront new questions regarding screening and prevention. This review highlights the screening for and prevention of breast...

journal_title：Current opinion in oncology

authors： Basil JB,Rader JS

更新日期：2000-09-01 00:00:00

abstract：:Our understanding of the pathogenesis and management of squamous cell carcinoma of the anal canal has undergone profound change over the last 30 years. Epidemiologic studies have demonstrated that infection with human papillomavirus is most likely responsible for the majority of cases. Primary treatment with concomita...

journal_title：Current opinion in oncology

authors： Ryan DP,Mayer RJ

更新日期：2000-07-01 00:00:00

abstract：:The prognosis of pediatric low-grade gliomas is relatively favorable, but residual or unresectable tumors remain a challenge. Conventional radiation therapy is effective but may be associated with unacceptable sequelae in young children. Chemotherapy can delay the need for radiation therapy in young children; however,...

journal_title：Current opinion in oncology

authors： Schmandt SM,Packer RJ

更新日期：2000-05-01 00:00:00

abstract：:The pathogenesis of prostate cancer reflects complex interactions among environmental and genetic factors. Recent advances suggest molecular mechanisms that may explain geographic and ethnic variations in prostate cancer incidence, and understanding of molecular disease progression is advancing rapidly. Clinically, th...

journal_title：Current opinion in oncology

authors： Small EJ,Reese DM

更新日期：2000-05-01 00:00:00

abstract：:Collaborative study groups have invested considerable effort in the last decade in defining the role of allogeneic and autologous bone marrow transplantation as consolidation treatment for first remission of acute myeloid leukemia in younger patients. These efforts have been able, more precisely, to quantitate the deg...

journal_title：Current opinion in oncology

authors： Burnett AK,Kell J

更新日期：2000-03-01 00:00:00

abstract：:Kaposi sarcoma (KS), an unusual tumor of vascular origin, was one of the first recognized manifestations of AIDS. In the past few years, it has become clear that human herpesvirus-8 (HHV-8) is critical to the development of KS in the setting of immunosuppression, such as that seen with HIV infection. Other genetic and...

journal_title：Current opinion in oncology

authors： Mitsuyasu RT

更新日期：2000-03-01 00:00:00

abstract：:Thyroid cancers are still the most common endocrine cancers. They are dominated by well-differentiated carcinomas, including papillary carcinoma, follicular carcinoma, and medullary thyroid carcinoma. Diagnosis is based on fine-needle aspiration cytologic examination. Recently, reverse transcription polymerase chain r...

journal_title：Current opinion in oncology

authors： Bi J,Lu B

更新日期：2000-01-01 00:00:00

abstract：:New data continue to refine our knowledge of systemic therapy for breast cancer. These include the third Oxford Overview on adjuvant systemic therapy, a small advantage of anthracycline regimens over CMF (cyclophosphamide, methotrexate, and 5-fluorouracil), and renewed interest in the "classic CMF" regimen. Primary ch...

journal_title：Current opinion in oncology

authors： Wolff AC

更新日期：1999-11-01 00:00:00

abstract：:Biologic approaches to lymphoma treatment are now a practical reality rather than a vaguely perceived hope for the future. Interferon alfa seems to have been established as a life-extending therapy for selected patients with follicular lymphoma. Humanized anti-CD20 monoclonal antibody (rituximab) has an authentic 50% ...

journal_title：Current opinion in oncology

authors： Bendandi M,Longo DL

更新日期：1999-09-01 00:00:00

abstract：:Although variation in diet may account for approximately one third of the variation in cancer incidence worldwide, epidemiologic studies have proven to be a blunt instrument for identifying causal relationships between intakes of specific food constituents and cancer risk at specific sites. Diets rich in fruits and ve...

journal_title：Current opinion in oncology

authors： Mathers JC,Burn J

更新日期：1999-09-01 00:00:00

abstract：:The ideal cancer therapy would accomodate the specific biology of a tumor and be based upon understanding the mechanisms of malignancy. This vision has been the driving force in cancer research. However, the story of success in clinical cancer management is a story of empirie largely independent from progress in basic...

journal_title：Current opinion in oncology

authors： Kovar H,Aryee D,Zoubek A

更新日期：1999-07-01 00:00:00

abstract：:Although early clinical gene therapy trials for recurrent central nervous system neoplasms showed the proof-of-principle, they did not fulfill the high expectations suggested by the preclinical experimental data. Insufficient distribution of vectors in human brain tumors and very low transduction efficiency require th...

journal_title：Current opinion in oncology

authors： Weyerbrock A,Oldfield EH

更新日期：1999-05-01 00:00:00

abstract：:The publication of the proceedings of Fourth Workshop on Carcinoma in situ was an impressive leap in our understanding of the interaction between prenatal and postpubertal factors in the development of germ cell cancer as well as increased insight into the molecular events that are involved in the development of these...

journal_title：Current opinion in oncology

authors： Oliver RT

更新日期：1999-05-01 00:00:00

abstract：:The appearance of skin lesions in patients with occult or obvious malignancy may be of extreme value in the detection and management of cancer because the skin is readily accessible to examination and biopsy. Examination of the skin of our patients can provide important insights into underlying malignant processes or ...

journal_title：Current opinion in oncology

authors： Sabir S,James WD,Schuchter LM

更新日期：1999-03-01 00:00:00

abstract：:Advances in the understanding of the cellular and molecular derangements involved in the initiation and progression of multiple myeloma are beginning to be translated into novel therapeutic approaches. The myeloma stem cell has been under intense scrutiny regarding its normal B-cell counterpart. Oncogenes, tumor-suppr...

journal_title：Current opinion in oncology

authors： Varterasian ML

更新日期：1999-01-01 00:00:00

abstract：:The past decade has been marked by an explosion of knowledge regarding the dysregulation of cancer at the molecular level. It has become apparent that oncogenes, tumor suppressor genes, and other ancillary molecules interact in complex pathways that govern cellular homeostasis. We review three molecular events that ha...

journal_title：Current opinion in oncology

authors： Dome JS,Look AT

更新日期：1999-01-01 00:00:00

abstract：:During the past year there have been a number of important advances in the area of systemic therapy for breast cancer. Combined chemoendocrine therapy has been shown to be more effective than tamoxifen alone in the adjuvant therapy of node-negative estrogen receptor-positive breast cancer. Preliminary results of a ran...

journal_title：Current opinion in oncology

authors： Dees EC,Kennedy MJ

更新日期：1998-11-01 00:00:00

abstract：:Seroepidemiologic studies show that Kaposi's sarcoma herpesvirus (KSHV) is more prevalent in those populations at higher risk to develop Kaposi's sarcoma (KS). Anti-KSHV antibody titer is also higher in those who develop KS. KSHV is a sexually transmitted disease among homosexual men, but other routes of transmission ...

journal_title：Current opinion in oncology

authors： Whitby D,Boshoff C

更新日期：1998-09-01 00:00:00

abstract：:Controversy exists over the role that environmental estrogens, such as pesticides or polychlorinated biphenyls (PCBs), might play as risk factors for breast cancer. Several laboratory studies have suggested that these chemicals function as weak estrogens, binding to the estrogen receptor and inducing various measures ...

journal_title：Current opinion in oncology

authors： Davidson NE

更新日期：1998-09-01 00:00:00

abstract：:In this review, recent advances in the clinical therapy of osteosarcoma, including results from the European Osteosarcoma Intergroup trial demonstrating the efficacy of a short intensive two drug protocol are discussed as well the evolving role of ifosfamide. Biologically, the area of interest on chromosome 3q, which ...

journal_title：Current opinion in oncology

authors： Himelstein BP

更新日期：1998-07-01 00:00:00

abstract：:Both paclitaxel and docetaxel have shown activity when used as a single agent in patients with squamous cell carcinoma of the head and neck (SCCHN). Combinations of both drugs with platinum derivatives and antimetabolites have been tested in patient populations with encouraging results, but some have exhibited conside...

journal_title：Current opinion in oncology

authors： Schrijvers D,Vermorken JB

更新日期：1998-05-01 00:00:00

abstract：:Chronic myelogenous leukemia (CML) is a hematologic malignancy characterized by an initial chronic phase of expanded clonal myelopoiesis followed by inevitable progression to accelerated phase and finally to fatal blast crisis. Although interferon therapy results in hematologic control of disease in most patients and ...

journal_title：Current opinion in oncology

authors： Enright H,McGlave P

更新日期：1998-03-01 00:00:00

abstract：:The currently used staging system in melanoma has not been significantly modified since 1988. While this four-stage system effectively stratifies patients into prognostic groups, additional discriminating criteria have been reported that is not presently incorporated in the staging system. The following additions and ...

journal_title：Current opinion in oncology

authors： Ross M

更新日期：1998-03-01 00:00:00

abstract：:The use of highly sensitive and specific assays to detect residual disease in patients with acute leukemia should provide a basis for optimizing therapy and maximizing each patient's chance of cure. Strategies for detecting residual disease are based on biologic properties that allow acute leukemia cells to be disting...

journal_title：Current opinion in oncology

authors： Baer MR

更新日期：1998-01-01 00:00:00

abstract：:Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind. Currently, three phosphatases have been implicated in the...

journal_title：Current opinion in oncology

authors： Parsons R

更新日期：1998-01-01 00:00:00